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Recent Research
Glycemic Index, Glycemic Load, and Risk of Digestive Tract Neoplasms: A Systematic Review and Meta-Analysis
Mulholland HG et al.
American Journal of Clinical Nutrition 2009 (Feb); 89: 568-576
A systematic review to assess the association between GI, GL and risk of digestive tract cancers. Cohort and case-control studies examining the risk between GI or GL and colorectal cancer and adenomas, pancreatic cancer, gastric cancer and squamous-cell oesophageal carcinoma were retrieved (n=23). There was a small, but non-significant increased risk of colorectal cancer for the highest level of GI intake, which was mostly due to case-control studies. Similar results were observed for GL and colorectal cancer risk. There was no association between pancreatic cancer risk and either GI or GL. Only two studies investigated the risk of stomach cancer: neither of these found and association with GI. One study (case-control) found a direct association with GL (OR 1.94, 95% CI 1.47-2.55), however the other study (cohort) did not find a significant association. One study (case-control) addressed oesophageal cancer. Borderline significant associations were found between squamous-cell oesophageal cancer risk and each 10-unit/d increase in GI intake (OR 1.1, 95% CI 0.9-1.5) and 100-unit/d increase in GL intake (OR 1.2, 95% CI 1.0-1.5).
April 2009
